Manufacturer 99% CAS 138890-62-7 Brinzolamide for Antiglaucoma Ocular Hypertension

Product Description
Manufacturer 99% CAS 138890-62-7 Brinzolamide for Antiglaucoma Ocular HypertensionBrinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Carbonic anhydrase is found primarily in erythrocytes(but also in other tissues including the eye). It exists as a number of isoenzymes, the most active of which is carbonic anhydrase II (CA-II).

Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.

   Certificate of Analysis

 

TEST SPECIFICATIONS RESULTS
Appearance White to yellow crystalline powder White crystalline powder
Identification A. Should meet the requirement Conforms
B. Should meet the requirement Conforms
Impurity A ≤0.5% N.D.
Impurity B ≤0.3% 0.075%
Loss on drying ≤0.5% 0.085%
Residue on Ignition ≤0.1% 0.045%
Residual solvent Ethanol≤0.5% 0.026%
Ethyl acetate≤0.5% N.D.
Tetrahydrofuran≤0.072% N.D.
Heavy Metal ≤20ppm Conforms
Assay 98.0%~102.0% (Calculated on the dried basis) 99.66%

Use for the treatment of open-angle glaucoma and raised intraocular pressure due to excess aqueous humor porduction.

Author: chemicals

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