Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.
Certificate of Analysis
|Appearance||White to yellow crystalline powder||White crystalline powder|
|Identification||A. Should meet the requirement||Conforms|
|B. Should meet the requirement||Conforms|
|Loss on drying||≤0.5%||0.085%|
|Residue on Ignition||≤0.1%||0.045%|
|Assay||98.0%~102.0% (Calculated on the dried basis)||99.66%|
Use for the treatment of open-angle glaucoma and raised intraocular pressure due to excess aqueous humor porduction.