Tetracaine HCl Alias: Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; Amethocaine hydrochloride
Tetracaine HCl CAS : 136-47-0
Tetracaine HCl Molecular formula: C15H25ClN2O2
Tetracaine HCl Molecular weight: 300.82
Tetracaine HCl EINECS: 205-248-5
Appearance: Fine white crystalline and odorless powder
Melting point: 145~150 degree
Grade: Pharmaceutical Grade
Usage: Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.
|Product name||Tetracaine HCl|
|Appearance||White crystalline powder|
|Identification||A.By UV, To match with working standard||Complies|
|B: Dissolve 100 mg in 10 mL of water, and add 1 mL of potassium thiocyanate
solution (1 in 4): a crystalline precipitate is formed. Recrystallize the precipitate
from water, and dry at 80 for 2 hours: it melts between 130 and 132 .
|C. A solution of 100 mg in 5 mL of water meets the requirements of the
Tests for Chloride
|Conform to standard||Complies|
|Solution should be clear||Complies|
|Related Substances||Not more than the reference solution (0.05%)||Complies|
|Loss on drying||<0.5%||0.21%|
|Resiue on ignition||≤0.1%||0.05%|
Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5‱ (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization’s List of Essential Medicines, a list of the most important medication needed in a basic health system.
A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties – however it did not find a statistically significant improvement in first attempt