Chemical Properties White Crystalline Powder
Usage The first totally synthetic monocyclic β-lactam antibiotic.
Packing: As customers requirments
Aztreonam known as ammonia triamcinolone, aminothiazolyl acid monoamine streptozotocin, aminothiazolyl carboxyl monoamine streptozotocin, Aztec aztreonam, bacteria gram single, Jun single moment, cefotaxime monobactam, the English name for Aztreonam, AZACTAM, Azactam, Aztreonamum, Primbactam, Primbactin, is a single-lactam ring type (Monobactams) New β- lactam antibiotics. In 1978, New Jersey, from the culture medium purple soil bacterium Bacillus Chromobacterium violaceum was first discovered, now with synthesis.
Aztreonam for bacteria fungicides. It can quickly through the outer membrane of Gram-negative aerobic bacteria wall, while the penicillin-binding protein 3 (PBP-3) with high affinity. By acting on the PBP-3, inhibition of bacterial cell wall synthesis, leading to cell lysis and death.
Aztreonam antimicrobial spectrum is narrow, only aerobic gram-negative bacilli with antibacterial effect, such as E. coli, Klebsiella, Serratia spp, Proteus mirabilis, indole-positive Proteus, Citrobacter, influenza addicted Blood coli, Pseudomonas aeruginosa and other Pseudomonas, some Enterobacter, Neisseria gonorrhoeae. The product of many bacteria within the β-lactamase highly stable. Gram-positive bacteria and anaerobes inactive. Aztreonam and ceftazidime, gentamicin, compared to aerogenes, Enterobacter cloacae role higher than ceftazidime, but lower than gentamicin; the role of Pseudomonas aeruginosa lower than ceftazidime with gentamicin close
Mainly for the treatment of respiratory infections caused by susceptible strains, urinary, reproductive system infections (including acute gonorrhea), abdominal infections, skin and soft tissue infections before surgery to prevent infection, other serious infections, such as sepsis.
Uses monocyclic β- lactam antibiotics against gram-negative bacteria have a strong antibacterial effect, and on the β- lactamase stability, but a plasmid or chromosome-mediated type 1 enzyme is slightly unstable. Respiratory tract caused by susceptible strains used in Gram-negative infections, urinary tract infections, biliary tract infections, abdominal infections, bone and joint infections, in combination with other drugs to treat gram-positive bacteria and anaerobic infections.
Mainly used for sensitive gram-negative bacteria caused the infection, including pneumonia, pleurisy, abdominal infections, biliary tract infections, bone and joint infections, skin and soft tissue inflammation, especially for urinary tract infections, but also for sepsis. Because this product has good resistance to enzyme performance, therefore, when the microorganism to penicillins, cephalosporins, aminoglycosides and other drugs is not sensitive to the FDA should always be effective.