99% High Purity  Female Steroids Powder Estradiol Benzoate CAS 50-50-0

Product Description
Product Description
99% High Purity  Female Steroids Powder Estradiol Benzoate CAS 50-50-0

Quick detail

Product Name: Estradiol Benzoate
Synonyms: 17-beta-Oestradiol 3-benzoate
CAS RN.: 50-50-0
EINECS: 200-043-7
Molecular Weight: 376.49
Molecular Formula: C25H28O3
purity 99%

Description:

Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock.
This compound binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol.

Application:

The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food and ethanol consumption were studied in ovarectomized rats given free access to food, a 10% ethanol solution, and water. EB led to an immediate, but transient, suppression of both food and ethanol intake. The time course and magnitude of these effects were virtually identical.

While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethanol consumption apparently resulted from decreased rates of licking within bouts. Gradual increases in the frequency of eating and ethanol-drinking bouts allowed total food and ethanol intake to return to baseline within three weeks of the first injection. Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethanol intake were discussed in terms of ethanol’s caloric property.

COA

Product name Estradiol Benzoate
Appearance White crystalline powder
Water ≤3.5% pass
Assay 97 .0~ 103.0% 99.2%
Loss on drying ≤0.5% 0.17%
Related substances total impurities ≤1.0% Pass
any individual impurity ≤0.5% Pass
Residual solvents ethanol ≤0.5% Pass

Estradiol Series:
Estradiol CAS: 50-28-2
Estradiol Benzoate CAS: 50-50-0
Estradiol Cypionate CAS: 313-06-4
Estradiol Enanthate CAS: 4956-37-0

Author: chemicals

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