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Isoproterenol hydrochloride is a phenethylamine derivative and selective β-AR adrenergic agonist shown to increase cytosolic cAMP. Isoproterenol hydrochloride exhibits promotion of glycogen breakdown and causes bronchodilation and vasorelaxant effects. Also potentially stimulates relaxation in nitric oxide mediated endothelium-dependent smooth muscle. Isoproterenol Hydrochloride is an activator of β2-AR and ERK.
Its primary use is for bradycardia or heart block. By activating β1 adrenergic receptor in the heart, it induces positive chronotropic, dromotropic, and inotropic effects.
It can be used as an inhaled aerosol to treat asthma, although this is currently a rare treatment.
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Product Name: Isoprenaline hydrochloride