Major depressive disorder (MDD) causes symptoms that interfere with a person’s ability to work, sleep, eat, and think. Almost 7% of American adults experience MDD symptoms each year. Symptoms include sadness, helplessness, hopelessness, difficulty concentrating, memory lapses, and the inability to make decisions.
Treating depression. It may also be used for other conditions as determined by your doctor.
Vortioxetine is an antidepressant. Exactly how it works to treat depression is not known. It is thought to work by restoring the balance of serotonin, a natural substance in the brain, which helps to improve certain mood problems.
Vortioxetine is an atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of serotonin. More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. SMSs were developed because there are many different subtypes of serotonin receptors, however, not all of these receptors appear to be involved in the antidepressant effects of SRIs. Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional role in the efficacy of SRIs in treating depression.